Neuroanatomical Profile

About Jon's Brain

A comprehensive structural MRI analysis revealing the neural architecture behind working memory fragility, cognitive compensation, and why some brains need external scaffolding to thrive.

43.71 Brain Age (Chron: 44)
1,709 cm³ Intracranial Volume
7 Analyses Completed

The Quick Version

My right cerebellum is doing disproportionate work, particularly a region called Lobule VI (+21% larger than the left). This enlarged structure projects through a normal thalamic relay to my left motor cortex, which is measurably thicker than the right (its biological age, on re-verification, matches the right side).

The left hemisphere reads "older" than the right on the structure-age model across nearly every paired structure, with the language regions furthest out front — but re-verification showed those same regions are also bigger and thicker than their mirrors, so the best reading is a brain built unusually lateralized, not one wearing down. Meanwhile, midline structures run smaller than average (brainstem, cerebellar vermis) while processing concentrates in the hemispheres.

The good news: overall brain age is normal (43.71 vs. my actual age of 44 — and an independent second model agrees), critical structures like the prefrontal cortex and basal ganglia are entirely typical, and a professional neuroradiology review found nothing to treat. The system is healthy; it's just built asymmetric — which, if you know me, explains a lot.

A Radiologist and a Re-Verification Weighed In

Two things happened since this page was written. First, an independent neuroradiology second opinion (board-certified, Swiss FMH/EDiNR) reviewed the underlying scan: the T1 is structurally unremarkable — no lesion, no atrophy, no malformation — and the one asymmetry flag that most worried me (a thalamic micro-structure at −72%) is visually symmetric and almost certainly a software measurement artifact, exactly what my own pipeline's QC notes suspected. Second, a full re-verification of every number on this page against the raw pipeline exports confirmed most of them — and overturned one framing.

The framing that changed: "wear" is probably the wrong word. The left-hemisphere language regions that read as "biologically older" are also thicker and larger than their right-side mirrors — the opposite of what aging or wear does to tissue. Leftward enlargement of language cortex is the most replicated normal asymmetry in the human brain, and the age model — trained on typical aging patterns — appears to be reading that normal lateralization as "older." The per-structure ages are also pipeline-relative (the model highlights anything ±5 years, and published cross-scanner comparisons show brain-age models disagree by 5–22 years between setups), so the absolute year-counts on this page are best read as relative rankings, not calendar time.

What survived verification unchanged: the right-cerebellar dominance (Lobule VI +21%), the midline reduction cluster (brainstem, vermis, 3rd ventricle — all outside the pipeline's own normative ranges), the uniformly left-older subcortex, and the classic left-larger language-area anatomy (planum temporale, frontal operculum), which reproduces across two independent atlases. The story is less "worn down by work" and more "unusually lateralized by construction" — which fits the working-memory architecture this page exists to explain.

Next step, per the radiologist: a dedicated clinical MRI with the sequences this research scan didn't include (FLAIR, DWI, SWI) — the ones that can actually answer the old-head-injury question (a helmetless ATV wreck my senior year of high school with a few minutes of memory loss, never evaluated at the time — now properly documented, and worth one real look).

Explain It Like I'm Five

🎯
The Lopsided Helper

Imagine one side of my "coordination center" (cerebellum) grew bigger to help out more. It's like having one really strong arm that does most of the lifting. It works, but that arm gets tired.

🔌
Normal Wiring

The "relay station" (thalamus) that passes messages between brain parts? Totally normal. Its pieces are working fine — one microscopic piece triggers a measurement glitch, and a radiologist confirmed it's the software, not the brain. The traffic jam isn't on the highway; it's at the destination.

💬
Built for Words

The parts that handle language are unusually big and thick on my left side. Most brains lean that way a little; mine leans hard. A computer model reads that as "older" — but it's more like a tailor mistaking a custom fit for wear. That's how this brain was built.

Leaning Left

Instead of using the middle parts of my brain equally, my brain shifted work to the sides, especially the left. It's like favoring one leg when you walk. You get there, but differently.

The Important Stuff Works

The "thinking" part (prefrontal cortex)? Normal size and thickness. The "habit" parts (basal ganglia)? All normal. The overall age of my brain? Perfect. The foundation is solid.

🏋
Custom Build, Not Broken

This isn't a "broken brain" story — and after a radiologist and a re-check of every number, it isn't a "worn out" story either. It's a custom build: unusual proportions, healthy parts, tuned for words and patterns. It runs the way it was built to run.

How It All Connects

Sender
Right Lobule VI
+21% enlarged
Relay Station
Left VL Nuclei
All motor relays normal
Receiver
Left Motor Cortex
+12% thicker; age = right side
The bottleneck is at the destination, not the pathway.
The right cerebellum is enlarged and generating more output. The thalamic relay is structurally normal. The left cortex is built up on the receiving end — thicker, not older.

Key Structural Findings

🧠

Right Cerebellar Dominance

The most robust finding, replicated across three independent analyses.

Structure Finding Normal Range Status
Total Cerebellum Asymmetry +7.70% R>L -2.86% to +4.47% Outside Normal
Lobule VI Asymmetry +21.23% R>L -15.72% to +14.87% Outside Normal
Cerebellar Gray Matter +8.37% R>L -1.70% to +5.97% Outside Normal
Cerebellar White Matter 1.40-1.76% 1.56-2.89% Below Normal

Left-Older Pattern (Structure-Age Model)

Every subcortical structure reads left-older on the structure-age model — 58 of 63 paired structures overall. Per the August 2026 update, read the year-figures as model-relative rankings, not calendar time.

Region Left Age Right Age Difference
Temporal Lobe (avg) 53.1 years 46.9 years L is 6.2 yrs older
Insular/Opercular (avg) 52.4 years 45.2 years L is 7.2 yrs older
Subcortical (avg) 48.7 years 45.2 years L is 3.5 yrs older
Right Occipital Pole 54.95 years 58.73 years +14.7 yrs above chrono

Notably Normal (Important Negatives)

Critical structures that are entirely typical, and often more informative than the differences.

Structure Finding Why It Matters
Prefrontal Cortex (Volume & Thickness) Normal Working memory issues aren't from obvious PFC deficits
Thalamic Nuclei (12 of 13) Normal The relay station is NOT the bottleneck. (The 13th, the ~20-voxel mammillothalamic sliver, flags at −72% — professionally confirmed as segmentation artifact, Aug 2026)
Basal Ganglia (all structures) Normal This is a cerebellar story, not a basal ganglia story
Total Hippocampus Normal Long-term memory architecture is intact
Overall Brain Age 43.71 years Global brain health is good (chrono: 44)

Midline Reduction Pattern

The brain appears organized away from midline processing toward lateralized processing.

Structure Finding Normal Range Status
Brainstem 1.12-1.23% 1.15-1.64% Below Normal
Cerebellar Vermis VI-VII 0.12-0.15% 0.15-0.23% Below Normal
3rd Ventricle 0.127-0.137% 0.006-0.123% Above Normal

The Interpretation

Not Broken, Just Different

This isn't a story of pathology or deficit. It's a story of a brain that organized itself differently, lateralizing processing, developing one cerebellar hemisphere more than the other, and adapting to its own architecture over 44 years.

The structures that read "older" on the age model are the same ones built biggest and thickest — the language and pattern machinery. That's not failure, and it turns out it isn't wear either; it's the anatomy of the specialization that does the compensating.

🔄 The Working Memory Connection

The prefrontal cortex is structurally normal (both volume and thickness). So why the working memory challenges? The answer may lie in circuit dynamics rather than local tissue deficits.

When the cerebellum (a "timing" and "prediction" structure) is asymmetric and the receiving cortex shows signs of strain, the coordination between structures may be where the challenge lives.

🗣 The Language Build

The left temporal lobe, home to language processing, is where the age model reads furthest ahead (7-10 pipeline-years) — and where the tissue is also largest and thickest relative to its mirror. For someone with constant internal verbal processing, recursive thinking, and decades of intense linguistic computation, the anatomy fits the life.

The build is where the work is.

🧩 Why External Scaffolding Matters

If the brain's internal coordination circuits are working at capacity, external tools become essential, not optional. The 700+ browser tabs, the detailed documentation systems, the AI partnerships for real-time processing... these aren't crutches.

They're appropriate infrastructure for a cognitive architecture that needs external buffering because the internal coordination systems are already running at full capacity.

Technical Deep Dive

Cerebellar Lobule-Level Analysis (CERES)

Detailed parcellation of all cerebellar lobules showing rightward asymmetry pattern.

Lobule Function Asymmetry Normal Range
Lobule VIMotor planning, cognition+21.23% R>L-15.72% to +14.87%
Crus IExecutive function+7.80% R>L-12.30% to +17.83%
Crus IICognitive processing+13.22% R>L-16.67% to +23.91%
Lobule VIIIASensorimotor+12.39% R>L-27.30% to +19.95%
Lobule VIIIBSensorimotor+12.93% R>L-28.82% to +26.98%
Lobule IXVestibular+4.92% R>L-9.69% to +15.90%
Hippocampal Subfield Analysis (HIPS)

Total hippocampus normal, but CA2-CA3 subfield shows rightward asymmetry.

Subfield Function Asymmetry Status
CA1Memory encoding/retrieval-3.31% L>RNormal
CA2-CA3Social memory, pattern separation+22.27% R>LOutside normal
CA4-DGPattern separation+8.35% R>LNormal
SubiculumOutput to cortex-3.68% L>RNormal
Thalamic Nuclei Detail (DeepThalamus)

12 of 13 thalamic nuclei within normal bounds. Motor relay nuclei show subtle leftward asymmetry consistent with receiving input from enlarged right cerebellum. The exception — the mammillothalamic nuclei, a ~0.02 cm³ sliver — flags at −72% asymmetry, which a 2026 professional neuroradiology read confirmed as segmentation artifact, not anatomy (the structures are visually symmetric).

Nucleus Function Volume % Status
VLPNMotor relay (cerebellum)0.121%Normal
VLANMotor relay (cerebellum)0.014%Normal
PulvinarVisual attention0.174%Normal
MediodorsalExecutive function0.093%Normal
VANMotor planning0.038%Normal
CentromedianArousal, attention0.018%Normal
LGNVisual relay0.010%Normal
MGNAuditory relay0.011%Normal
Brain Structure Ages by Region

Biological age estimates for brain regions. Left hemisphere consistently older.

Structure Right Age Left Age Chronological: 44
Planum Temporale47.1254.46+10.5 yrs (L)
Sup. Temporal Gyrus46.9754.16+10.2 yrs (L)
Frontal Operculum43.2452.41+8.4 yrs (L)
Hippocampus45.9050.21+6.2 yrs (L)
Putamen45.1349.52+5.5 yrs (L)
Thalamus45.0147.84+3.8 yrs (L)
Occipital Pole58.7354.95+14.7 yrs (R)
Cortical Thickness Measurements (vol2Brain)

Cortical thickness across regions. Prefrontal cortex is normal, a critical negative finding.

Region Thickness Status
Frontal Lobe (total)2.37 mmNormal
Middle Frontal Gyrus2.28 mmNormal
Superior Frontal Gyrus1.92 mmNormal
Precentral Gyrus1.68 mmNormal
Precentral Gyrus (L vs R)1.78 vs 1.58 mmLeft 11.8% thicker
Temporal Lobe3.15 mmNormal
Parietal Lobe1.90 mmNormal
Occipital Lobe2.26 mmNormal
Quality & Methodology Notes

Data quality metrics and analysis pipeline details.

Analysis SNR / Quality Confidence
vol2BrainSNR 41.15HIGH
AssemblyNetSNR 41.26, QC: AHIGH
BrainStructureAgesQC: AHIGH
DeepThalamusScale 0.96HIGH
CERESSNR 32.23HIGH
HIPSScale 0.96HIGH
pBrainSNR 17.50LOW (interpret with caution)

Full Volumetric Reports

Interactive pages with complete measurements from each volBrain analysis pipeline. Click any available report to explore the full dataset.

AssemblyNet
Available
Comprehensive whole-brain segmentation using deep learning to identify 88 anatomical structures. Provides absolute volumes (cm³), percentages relative to intracranial cavity, and hemisphere asymmetry indexes. Compares measurements against age/sex-matched normative data to flag structures outside expected ranges. This is useful for detecting atrophy patterns associated with neurological conditions.
vol2Brain
Coming Soon
Measures cortical thickness across all brain regions, providing millimeter-precise measurements of the grey matter ribbon. Also includes tissue-level segmentation (white matter, grey matter, CSF) and normalized volumes. Cortical thinning is an early biomarker for many neurodegenerative conditions, making this analysis valuable for tracking subtle changes over time.
CERES
Available
Specialized cerebellar parcellation that segments the cerebellum into individual lobules (I-X), Crus I/II, and vermis regions. The cerebellum plays critical roles in motor coordination, cognitive timing, and prediction. Lobule-specific volumes can reveal patterns of compensation or asymmetry not visible in whole-cerebellum measures.
HIPS
Available
High-resolution hippocampal subfield segmentation identifying CA1, CA2-CA3, CA4-DG, and subiculum volumes separately. These subfields have distinct functions in memory encoding, pattern separation, and spatial navigation. Subfield-specific atrophy is an early indicator of Alzheimer's disease, often detectable before whole-hippocampus volume loss.
DeepThalamus
Available
Segments the thalamus into 13 distinct nuclei including pulvinar, mediodorsal, VL/VA motor nuclei, and sensory relay nuclei (LGN, MGN). The thalamus acts as the brain's central relay station, and nucleus-specific measurements can reveal whether information flow bottlenecks exist in motor, sensory, or cognitive pathways.
BrainStructureAges
Available
Estimates biological age for individual brain structures using machine learning models trained on large normative datasets. Reveals which regions are aging faster or slower than expected: for example, language regions showing 7+ years of accelerated aging while motor regions remain typical. Provides insight into regional wear patterns from cognitive demands.
pBrain
Coming Soon
Segments the small monoamine-system brainstem nuclei: red nucleus, substantia nigra, and subthalamic nucleus. At this scan's SNR the pBrain output is unreliable for these tiny structures (its raw values include anatomically implausible asymmetries), so it is treated as low-confidence and its measurements are deliberately not imported.

Methodology

Structural MRI acquired as part of a UT Austin research study in May 2024. Analysis performed using volBrain's cloud-based neuroimaging platform.

Image Source UT Austin Research Study, May 2024
Resolution 0.8mm isotropic (T1-weighted + T2-weighted sequences)
Quality Grade Research-grade, superior to standard clinical 1mm resolution
Analysis Platform volBrain (7 specialized neuroimaging pipelines)
Normative Comparison Age and sex-matched reference data with 95% confidence intervals
Cross-Validation Key findings replicated across 2-3 analyses (several share one segmentation family; a 2026 cross-atlas check reproduced the classic language-area asymmetries but not every secondary finding — see the August 2026 update above)
Professional Review Independent neuroradiology second opinion (FMH/EDiNR, Aug 2026): T1 structurally unremarkable; flagged micro-structure asymmetry confirmed as measurement artifact
"Understanding my own brain architecture isn't just personal curiosity. It's proof of concept for what's possible when AI helps humans understand themselves deeply."

This is why I'm building AIs & Shine. Because if structural MRI data, AI-assisted analysis, and careful synthesis can reveal this level of insight about one brain, imagine what "Life Models" could do for millions of people who experience their minds differently.


Human. Deeply seen.
That's not just a tagline. It's what this page represents.